Monthly Archives: March 2010

How to prevent N-Cbz from falling off in hydrogenation condition ?

N-Cbz is sensitive to H2/pd/c even in basic condition (TEA).Known methods to prevent N-Cbz from falling off when doing hydrogenation reactions are not many. 1. Pd/c (en), H2, THF by Kosaku Hirotapd/c (en) is pd/c deactivated by ethylenediamine. It is … Continue reading

Posted in deprotection, hydrogenation, protection | 4 Comments