Category Archives: S
proposal of synthesis of namenamicin
Namenamicin is a enediyne. the construction of the sulfur-containing quartery center is the critical part of the synthesis. This proposal uses a thionium ion to directly form the quartery center which can lead to the desired structure in an efficient … Continue reading
Swern oxidation typical procedure
Procedure: 25 mL 1-neck flask, stirbar, septum, N2 inlet Dissolved 0.077 mL of oxalylchloride (II) in 4.0 mL of dry CH2Cl2. Stirred; cooled to -78 C. Added 0.125 mL of DMSO. Stirred 10 min. Added a solution of 0.096 g … Continue reading
Sulfur containing quaternary carbon center
How to build a S-containing quaternary carbon centerlike this: ways I can find out:1. enolate attack a S-nucleophile. ex. MeSSMe.2. 3,3-sigmatropic rearrangement.3. thioketone attacked by a Nu-.4. thiol 1,4-addition.5. thionium ions (ex. from thiolketal) attacked by a Nucleophile.6. methoxyphenylthiomethyllithium addition … Continue reading
A novel synthesis of silyl enol ethers from a-silylbenzylthiols and carboxylic acid derivatives via C—C bond formation
Tetrahedron Letters Volume 42, Issue 52, 24 December 2001, Pages 9221-9223 A new procedure for the synthesis of silyl enol ethers from S–-silylbenzyl thioesters without need for either bases or catalysts via C—C bond formation is described. Solutions of S–-silylbenzyl … Continue reading
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